WELCOME TO THE MAQC SOCIETY

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Important Announcement

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Due to the international COVID -19 pandemic, the MAQC Society rescheduled the MAQC Society 2020 Meeting at SAS Institute in Cary, NC for April 28-30, 2021 at the SAS Institute (same location).  A sister organization, MCBIOS, will be planning to meet April 26-28, 2021.

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New MAQC Society Project Proposal

Inflammation as class of biological mechanisms underlies a spectrum of diseases and poses a unique opportunity to understand both its fundamental (core) and disease-state specific features.  With the emergence of single-cell sequencing (e.g., scRNA-seq), there are now competing methods to traditional immunohistochemstry (IHC) tests, single- to multiplexed ELISAs, and flow cytometry methods for identifying and classifying individual cell types of interest.  Therefore, we would like to form a MAQC Society project and Working Group(s) devoted to assays associated with inflammatory diseases.  For more information go to the
New MAQC Society Projects page.

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The objective of the MAQC Society is to communicate, promote, and advance reproducible science principles and quality control for analysis of the massive data generated from the existing and emerging technologies in solving biological, health, and medical problems. Thus, the goals of the Society are to (1) advocate and facilitate the development and application of quality control practice and standard analysis protocols of bioinformatics and biostatistics for enhanced reproducibility across multiple experiments, laboratories, and data analysis methods, and (2) advance our understanding and best practices in the analysis of massive data from emerging technologies applied in drug development, clinical application, and safety/risk assessment.

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MAQC SOCIETY AT A GLANCE

A Bit of Background

Historically, the MAQC/SEQC has been a US FDA‐led community-wide consortium effort to address issues relating to the application of constantly evolving high‐throughput genomics technologies to either assess safety and efficacy of FDA regulated products or their safe and effective use in clinical applications as in vitro diagnostic devices. The MAQC consortium completed three projects between 2005 ‐2014 (namely MAQC I, II and III/SEQC), resulting in ~30 publications, one third of which were published in Nature Biotechnology. Furthermore, two of these papers were among the most cited in Nature Biotechnology in the last 20 years. The MAQC Society is currently completing work on SEQC2 resulting in additional publications in Nature Biotechnology and other journals regarding best practices in DNA analysis.  Additional information about MAQC Consortium projects is available here.  The success enjoyed by consortium members led us to create a new society whose mission is to promote reproducible scientific research, especially research that involves analysis of massive data sets but which include additional areas benefiting human health: medical and pathology imaging, proteomics and other -omics, large health-related studies and databases, etc.

 

Recent Activities and Meetings

MAQC Workshops, Key Publications, and Society Meetings

 

3rd Annual Meeting of the MAQC Society

April 8-10, 2019

Reproducibility for Artificial Intelligence in Medicine

Riva Del Garda, Trentino, Italy

Inaugural Meeting of Little Rock Chapter of MAQC Society

Sept 7-8, 2018

Comprehensive Assessments of NGS Onco-panel Technologies

Univ of Arkansas for Medical Sciences (UAMS), Little Rock, AR

2nd Annual Meeting of the MAQC Society

Feb 24-27, 2018

Precision Medicine in Clinical Omics

Shaghai, China

Inaugural Meeting of the MAQC Society

April 12, 2017

SAS Institute, Cary, NC

SEQC Nature Biotechnology and other Publications

August 2014

Su Z, Łabaj PP, Li S, Thierry-Mieg J, Thierry-Mieg D, Shi W, Wang C, Schroth GP, Setterquist RA, Thompson JF, Jones WD. A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium. Nature biotechnology. 2014 Sep;32(9):903.

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Li S, Łabaj PP, Zumbo P, Sykacek P, Shi W, Shi L, Phan J, Wu PY, Wang M, Wang C, Thierry-Mieg D. Detecting and correcting systematic variation in large-scale RNA sequencing data. Nature biotechnology. 2014 Sep;32(9):888.

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Wang C, Gong B, Bushel PR, Thierry-Mieg J, Thierry-Mieg D, Xu J, Fang H, Hong H, Shen J, Su Z, Meehan J. The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance. Nature biotechnology. 2014 Sep;32(9):926.

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Gong B, Wang C, Su Z, Hong H, Thierry-Mieg J, Thierry-Mieg D, Shi L, Auerbach SS, Tong W, Xu J. Transcriptomic profiling of rat liver samples in a comprehensive study design by RNA-Seq. Scientific data. 2014 Aug 26;1:140021.

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Munro SA, Lund SP, Pine PS, Binder H, Clevert DA, Conesa A, Dopazo J, Fasold M, Hochreiter S, Hong H, Jafari N. Assessing technical performance in differential gene expression experiments with external spike-in RNA control ratio mixtures. Nature communications. 2014 Sep 25;5:5125.

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MAQC-II Nature Biotechnology and Pharmacogenomics Publications

August, 2010

Shi L, Campbell G, Jones WD, Campagne F, Wen Z, Walker SJ, Su Z, Chu TM, Goodsaid FM, Pusztai L, Shaughnessy Jr JD, et al. The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models. Nature biotechnology. 2010 Aug;28(8):827.

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Tillinghast GW. Microarrays in the clinic. Nature biotechnology. 2010 Aug;28(8):810.

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Fan X, Lobenhofer EK, Chen M, Shi W, Huang J, Luo J, Zhang J, Walker SJ, Chu TM, Li L, Wolfinger R. Consistency of predictive signature genes and classifiers generated using different microarray platforms. The pharmacogenomics journal. 2010 Aug;10(4):247.

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Parry, R.M., Jones, W. D., Stokes, T. H., et al. (2010) k-Nearest neighbor models for microarray gene expression analysis and clinical outcome prediction, Pharmacogenomics, J 10: 292-309; doi:10.1038/ tpj.2010.56. 

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Shi W, Bessarabova M, Dosymbekov D, Dezso Z, Nikolskaya T, Dudoladova M, Serebryiskaya T, Bugrim A, Guryanov A, Brennan RJ, Shah R. Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes. The pharmacogenomics journal. 2010 Aug;10(4):310.

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Oberthuer A, Juraeva D, Li L, Kahlert Y, Westermann F, Eils R, Berthold F, Shi L, Wolfinger RD, Fischer M, Brors B. Comparison of performance of one-color and two-color gene-expression analyses in predicting clinical endpoints of neuroblastoma patients. The pharmacogenomics journal. 2010 Aug;10(4):258.

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Luo J, Schumacher M, Scherer A, Sanoudou D, Megherbi D, Davison T, Shi T, Tong W, Shi L, Hong H, Zhao C. A comparison of batch effect removal methods for enhancement of prediction performance using MAQC-II microarray gene expression data. The pharmacogenomics journal. 2010 Aug;10(4):278-91.

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Hong H, Shi L, Su Z, Ge W, Jones WD, Czika W, Miclaus K, Lambert CG, Vega SC, Zhang J, Ning B. Assessing sources of inconsistencies in genotypes and their effects on genome-wide association studies with HapMap samples. The pharmacogenomics journal. 2010 Aug;10(4):364.

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10th MAQC Project Meeting - Inaugural SEQC Meeting

Dec 16-17, 2008

US FDA, Silver Spring, MD

9th MAQC Project Meeting

Sept 18-19, 2008

Best Practices for Developing and Validating Microarray-Based Predictive Models

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US FDA, 10903 New Hampshire Ave, Silver Spring MD

Reproducibility, Sensitivity, and Specificity Publication from MAQC

August 2008

Shi, L, Jones, WD, Jensen, RV, et al. (2008). The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies, BMC Bioinformatics, 9(Suppl 9):S10.

8th MAQC Project Meeting

March 24-26, 2008

Development and Validation of Predictive Models

US FDA, Rockville, MD

7th MAQC Project Meeting

May 24-25, 2007

Development and Validation of Predictive Models

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SAS Institute, Cary, NC

6th MAQC Project Meeting

Nov 28-29, 2006

Washington, Marriott Hotel and the FDA White Oak Facility, Silver Spring, MD

MAQC Nature Biotechnology Publications

Sept, 2006

Shi L, Reid LH, Jones WD, Shippy R, Warrington JA, Baker SC, Collins PJ, De Longueville F, Kawasaki ES, Lee KY, Luo Y, et al. The MicroArray Quality Control (MAQC) project shows inter-and intraplatform reproducibility of gene expression measurements. Nature biotechnology. 2006 Sep;24(9):1151.

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Guo L, Lobenhofer EK, Wang C, Shippy R, Harris SC, Zhang L, Mei N, Chen T, Herman D, Goodsaid FM, Hurban P. Rat toxicogenomic study reveals analytical consistency across microarray platforms. Nature biotechnology. 2006 Sep;24(9):1162.

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Canales RD, Luo Y, Willey JC, Austermiller B, Barbacioru CC, Boysen C, Hunkapiller K, Jensen RV, Knight CR, Lee KY, Ma Y. Evaluation of DNA microarray results with quantitative gene expression platforms. Nature biotechnology. 2006 Sep;24(9):1115.

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Shippy R, Fulmer-Smentek S, Jensen RV, Jones WD, Wolber PK, Johnson CD, Pine PS, Boysen C, Guo X, Chudin E, Sun YA. Using RNA sample titrations to assess microarray platform performance and normalization techniques. Nature biotechnology. 2006 Sep;24(9):1123.

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Patterson TA, Lobenhofer EK, Fulmer-Smentek SB, Collins PJ, Chu TM, Bao W, Fang H, Kawasaki ES, Hager J, Tikhonova IR, Walker SJ. Performance comparison of one-color and two-color platforms within the MicroArray Quality Control (MAQC) project. Nature biotechnology. 2006 Sep;24(9):1140.

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Tong W, Lucas AB, Shippy R, Fan X, Fang H, Hong H, Orr MS, Chu TM, Guo X, Collins PJ, Sun YA. Evaluation of external RNA controls for the assessment of microarray performance. Nature biotechnology. 2006 Sep;24(9):1132.

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5th Face-to-Face MAQC Consortium Meeting

Sept 21, 2006

National Center for Toxicological Research, FDA, Jefferson, AR

4th Face-to-Face MAQC Consortium Meeting

Feb 3-4, 2006

UMass, Boston, MA

3rd Face-to-Face MAQC Consortium Meeting

Dec 1-2, 2005

Palo Alto, CA

Initial MAQC Consortium Meeting

May 2-3, 2005

The MAQC Project: Calibrated RNA Samples, Reference Datasets, and QC Metrics/Thresholds

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FDA Parklawn Building, 5600 Fisher's Lane, Rockville, MD  20857

Kohn's Second Law: An experiment is reproducible until another laboratory tries to repeat it

Alexander Kohn

We should be asking, 'How much of an effect is there?', not 'Is there an effect?'”

Geoff Cumming

 
 
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MAQC Society Board of Directors

A Board of Directors is chartered to develop the Society and oversee the Society’s activities. Specifically, the Board is dedicated to building and strengthening the reproducible science practice by (1) engaging scientists in academia, industry, and government, (2) fostering collaboration and harmonization of education, research tools, and new technologies, and (3) building the global-scientific infrastructure needed to advance and promote reproducible science.

Dr. Weida Tong

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Chairperson of the Board - MAQC Society

Director, Division of Bioinformatics and Biostatistics NCTR/FDA

Bio

Dr. Wendell Jones

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President

Principal Bioinformaticist and Scientific Advisor  Q2 Solutions/EA Genomics

Bio

Dr. Joaquin Dopazo

Vice President

Head of the Clinical Bioinformatics Area
Fundacion Progreso y Salud

Dr. Rebecca Kusko

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Deputy Chairperson

SVP, Head of Research and Development

Immuneering Corporation

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Dr. Shraddha Thakkar

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Executive Secretary

Research Biologist — Division of Bioinformatics and Biostatistics, FDA-NCTR

Dr. Wenjun Bao

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Treasurer

Chief Scientist and Sr. Manager

JMP Life Sciences, SAS Institute

Dr. Xiaohui Fan

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President-Elect

Professor and Vice Dean

College of Pharmaceutical Sciences

Zhejiang University

Dr. Leming Shi

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Board Member, Past President

Distinguished Professor in School of Life Sciences

Fudan University

Dr. Cesare Furlanello

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Board Member, Past President

Head of Data Science and of the MPBA,  Fondazione Bruno Kessler (FBK)

Dr. Chris Mason

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Board Member

Associate Professor

Director, WorldQuant (WQ) Init. for Quantitative Prediction & WQ Scholar

Weill Cornell Medicine

Dr. Benjamin Haibe-Kains

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Board Member

Scientist, Princess Margaret Cancer Center University Health Network

Assistant Professor, Department of Medical Biophysics University of Toronto

Dr. Russ Wolfinger

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Board Member

Director of Scientific Discovery and Genomics

SAS Institute/JMP Genomics

Dr. Susanna Sansone 

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Board Member

Associate Professor, Data Readiness

Department of Engineering Science, University of Oxford

Dr. Matthias Fischer

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Board Member

Professor and Senior Physician

Experimental Pediatric Oncology

University Children's Hospital, Cologne, Germany

L-R Back Row: Dr. Weida Tong, Dr. Joaquin Dopazo, Dr. Cesare Furlanello, Dr. Leming Shi, Dr. Matthias Fischer, Dr. Christopher Mason, Dr. Benjamin Haibe-Kains, Dr. Russell Wolfinger, Dr. Wendell Jones

L-R Front Row: Dr. Wenjun Bao, Dr. Rebecca Kusko, Dr. Shraddha Thakkar, Dr. Susanna Sansone 

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